An essential brain-forming enzyme is glycosylation

According to a study, the MGAT5 glycosylation enzyme plays a crucial role in brain development, opening up the possibility of novel uses for neural stem cells.According to a study from the University of California, Irvine, the MGAT5 glycosylation enzyme is crucial for brain development. This discovery could result in novel therapeutic uses for neural stem cells.Neurons, astrocytes, and oligodendrocytes are the final mature cells to form in the brain and spinal cord from neural stem cells. Each has a specific and significant role. Neurons transmit signals, astrocytes modify them, and oligodendrocytes protect them from degeneration. Whenever any cells create proteins or fats that end up on the cell surface, little sugar molecules are typically added.

According to the study, which was published in the journal Stem Cell Reports, the MGAT5 enzyme strongly controls the differentiation of neural stem cells into neurons and astrocytes during the glycosylation process. During the very early phases of brain development, neural stem cells lacking MGAT5 produce more neurons and fewer astrocytes, changing the shape of the brain. Later aberrant behaviour patterns, such as improper social interactions and repetitive conduct, may be influenced by these alterations.We now have a better understanding of how the development of our nervous system proceeds, according to corresponding author Lisa Flanagan, professor of neurology at the School of Medicine at the University of California, Irvine. We anticipate that these results will advance the therapeutic application of brain stem cells by presenting